Contribution of platelets to tumour metastasis
LJ Gay, B Felding-Habermann - Nature Reviews Cancer, 2011 - nature.com
LJ Gay, B Felding-Habermann
Nature Reviews Cancer, 2011•nature.comExtensive experimental evidence shows that platelets support tumour metastasis. The
activation of platelets and the coagulation system have a crucial role in the progression of
cancer. Within the circulatory system, platelets guard tumour cells from immune elimination
and promote their arrest at the endothelium, supporting the establishment of secondary
lesions. These contributions of platelets to tumour cell survival and spread suggest platelets
as a new avenue for therapy.
activation of platelets and the coagulation system have a crucial role in the progression of
cancer. Within the circulatory system, platelets guard tumour cells from immune elimination
and promote their arrest at the endothelium, supporting the establishment of secondary
lesions. These contributions of platelets to tumour cell survival and spread suggest platelets
as a new avenue for therapy.
Abstract
Extensive experimental evidence shows that platelets support tumour metastasis. The activation of platelets and the coagulation system have a crucial role in the progression of cancer. Within the circulatory system, platelets guard tumour cells from immune elimination and promote their arrest at the endothelium, supporting the establishment of secondary lesions. These contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.
nature.com