[HTML][HTML] FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics
FMJ Jacobs, LP Van der Heide, PJEC Wijchers… - Journal of Biological …, 2003 - ASBMB
Forkhead transcription factors of the FoxO-group are associated with cellular processes like
cell cycle progression and DNA-repair. FoxO function is regulated by protein kinase B (PKB)
via the phosphatidylinositol 3-kinase/PKB survival pathway. Phosphorylation of serine and
threonine residues in specific PKB phosphorylation motifs leads to exclusion of FoxO-
proteins from the nucleus, which excludes them from exerting transactivating activity.
Members of the FoxO-group have three highly conserved regions containing a PKB …
cell cycle progression and DNA-repair. FoxO function is regulated by protein kinase B (PKB)
via the phosphatidylinositol 3-kinase/PKB survival pathway. Phosphorylation of serine and
threonine residues in specific PKB phosphorylation motifs leads to exclusion of FoxO-
proteins from the nucleus, which excludes them from exerting transactivating activity.
Members of the FoxO-group have three highly conserved regions containing a PKB …