[HTML][HTML] The microbiome and hematopoietic cell transplantation: past, present, and future
Biology of Blood and Marrow Transplantation, 2018•Elsevier
Highlights•Microbiome alterations are associated with infection, GVHD, and other adverse
transplant outcomes.•“Multiomic” technologies may better identify clinically actionable
microbiome biomarkers.•Functional microbial characterization may improve diagnostic and
therapeutic strategies.•Knowledge gaps persist in chronic GVHD and extraintestinal
microbiome-host interactions.•Multi-institutional studies and data collection expansion will
maximize microbiome research impact.
transplant outcomes.•“Multiomic” technologies may better identify clinically actionable
microbiome biomarkers.•Functional microbial characterization may improve diagnostic and
therapeutic strategies.•Knowledge gaps persist in chronic GVHD and extraintestinal
microbiome-host interactions.•Multi-institutional studies and data collection expansion will
maximize microbiome research impact.
Highlights
- Microbiome alterations are associated with infection, GVHD, and other adverse transplant outcomes.
- “Multiomic” technologies may better identify clinically actionable microbiome biomarkers.
- Functional microbial characterization may improve diagnostic and therapeutic strategies.
- Knowledge gaps persist in chronic GVHD and extraintestinal microbiome-host interactions.
- Multi-institutional studies and data collection expansion will maximize microbiome research impact.
Elsevier