Androgen-regulated cervical ripening: a structural, biomechanical, and molecular analysis
H Ji, TL Dailey, V Long, EK Chien - American journal of obstetrics and …, 2008 - Elsevier
OBJECTIVE: Androgens regulate biomechanical responses in load-bearing tissues.
Evidence suggests that androgens may play a role in the cervix. We hypothesized that
androgens directly regulate cervical remodeling by altering both collagen structure and
proteoglycan composition. STUDY DESIGN: Cervical resistance was evaluated using the
cervical creep method after the administration of intravaginal dihydrotestosterone or oral
flutamide. Microstructural changes in collagen were evaluated by transmission electron …
Evidence suggests that androgens may play a role in the cervix. We hypothesized that
androgens directly regulate cervical remodeling by altering both collagen structure and
proteoglycan composition. STUDY DESIGN: Cervical resistance was evaluated using the
cervical creep method after the administration of intravaginal dihydrotestosterone or oral
flutamide. Microstructural changes in collagen were evaluated by transmission electron …