Risk of preterm delivery in non-diabetic women with polycystic ovarian syndrome
M Yamamoto, SL Feigenbaum, Y Crites… - Journal of …, 2012 - nature.com
M Yamamoto, SL Feigenbaum, Y Crites, GJ Escobar, J Yang, A Ferrara, JC Lo
Journal of perinatology, 2012•nature.comObjective: To examine the risk and etiology of preterm delivery in women with polycystic
ovary syndrome (PCOS). Study Design: Retrospective cohort study comparing preterm
delivery rate among non-diabetic PCOS and non-PCOS women with singleton pregnancy.
Multivariable logistic regression was used to identify predictors of preterm delivery among
PCOS women. Result: Among 908 PCOS women with singleton pregnancy, 12.9%
delivered preterm compared with 7.4% among non-PCOS women (P< 0.01). Causes of …
ovary syndrome (PCOS). Study Design: Retrospective cohort study comparing preterm
delivery rate among non-diabetic PCOS and non-PCOS women with singleton pregnancy.
Multivariable logistic regression was used to identify predictors of preterm delivery among
PCOS women. Result: Among 908 PCOS women with singleton pregnancy, 12.9%
delivered preterm compared with 7.4% among non-PCOS women (P< 0.01). Causes of …
Abstract
Objective:
To examine the risk and etiology of preterm delivery in women with polycystic ovary syndrome (PCOS).
Study Design:
Retrospective cohort study comparing preterm delivery rate among non-diabetic PCOS and non-PCOS women with singleton pregnancy. Multivariable logistic regression was used to identify predictors of preterm delivery among PCOS women.
Result:
Among 908 PCOS women with singleton pregnancy, 12.9% delivered preterm compared with 7.4% among non-PCOS women (P< 0.01). Causes of preterm delivery among PCOS women included preterm labor (41%), cervical insufficiency (11%), hypertensive complications (20%), preterm premature rupture of membranes (15%), fetal–placental concerns (9%) and intrauterine fetal demise (5%). Maternal age, race/ethnicity and nulliparity were significant predictors of preterm delivery in PCOS, whereas body mass index and fertility medications were not.
Conclusion:
A higher proportion of PCOS women delivered preterm (12.9%) compared with non-PCOS women, with the majority of cases due to spontaneous preterm birth. Future studies should explore etiologies and strategies to improve pregnancy outcomes in PCOS.
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