Effects of the nonsteroidal aromatase inhibitor, fadrozole, on the sexual behavior of male cynomolgus monkeys (Macaca fascicularis)
D Zumpe, RW Bonsall, RP Michael - Hormones and behavior, 1993 - Elsevier
In many vertebrates, castration and hormone replacement and, more recently, the use of
aromatase inhibitors, have shown that male sexual activity is mediated by the aromatization
of testosterone (T) to estradiol (E 2). In macaques, however, the systemic administration of E
2, either alone or in combination with androgen, failed either to maintain or to restore the
sexual activity of castrated males. The present study examines the effects of administering
the nonsteroidal aromatase inhibitor, Fadrozole, either alone or combined with E 2, to …
aromatase inhibitors, have shown that male sexual activity is mediated by the aromatization
of testosterone (T) to estradiol (E 2). In macaques, however, the systemic administration of E
2, either alone or in combination with androgen, failed either to maintain or to restore the
sexual activity of castrated males. The present study examines the effects of administering
the nonsteroidal aromatase inhibitor, Fadrozole, either alone or combined with E 2, to …