Sex-steroid hormones and EGF signalling in breast and prostate cancer cells: targeting the association of Src with steroid receptors
Sex-steroid hormones trigger association of their receptors with signalling effectors.
Remarkably, various hormonal effects, such as DNA synthesis of different cell types are
evoked by this association. In mammary and prostate cancer cells, EGF, androgen or
estradiol trigger the assembly of AR/ER/Src complex. SH2-Src interacts with a
phosphotyrosine residue of ER and SH3-Src interacts with a proline rich sequence of AR.
This association stimulates Src-dependent signalling, DNA synthesis and cytoskeleton …
Remarkably, various hormonal effects, such as DNA synthesis of different cell types are
evoked by this association. In mammary and prostate cancer cells, EGF, androgen or
estradiol trigger the assembly of AR/ER/Src complex. SH2-Src interacts with a
phosphotyrosine residue of ER and SH3-Src interacts with a proline rich sequence of AR.
This association stimulates Src-dependent signalling, DNA synthesis and cytoskeleton …