[HTML][HTML] Enhanced lysosomal pathology caused by β-synuclein mutants linked to dementia with Lewy bodies
J Wei, M Fujita, M Nakai, M Waragai, K Watabe… - Journal of biological …, 2007 - ASBMB
Two missense mutations (P123H and V70M) of β-synuclein (β-syn), the homologue of α-syn,
have been recently identified in dementia with Lewy bodies. However, the mechanism
through which these mutations influence the pathogenesis of dementia with Lewy bodies is
unclear. To investigate the role of the β-syn mutations in neurodegeneration, each mutant
was stably transfected into B103 neuroblastoma cells. Cells overexpressing mutated β-syn
had eosinophilic cytoplasmic inclusion bodies immunopositive for mutant β-syn, and …
have been recently identified in dementia with Lewy bodies. However, the mechanism
through which these mutations influence the pathogenesis of dementia with Lewy bodies is
unclear. To investigate the role of the β-syn mutations in neurodegeneration, each mutant
was stably transfected into B103 neuroblastoma cells. Cells overexpressing mutated β-syn
had eosinophilic cytoplasmic inclusion bodies immunopositive for mutant β-syn, and …