Prorenin receptor is essential for podocyte autophagy and survival
F Riediger, I Quack, F Qadri, B Hartleben… - Journal of the …, 2011 - journals.lww.com
The prorenin receptor (PRR) is highly expressed in podocytes, but its role in the
maintenance of podocyte function is unknown. Here we generated podocyte-specific PRR-
knockout mice and found that these animals died between 2 to 3 wk after birth. Within 14 d,
PRR-knockout mice developed nephrotic syndrome, albuminuria with podocyte foot-process
fusion, and cytoskeletal changes. Podocyte-specific PRR deletion also led to disturbed
processing of multivesicular bodies and enrichment of autophagosomal (LC3) and …
maintenance of podocyte function is unknown. Here we generated podocyte-specific PRR-
knockout mice and found that these animals died between 2 to 3 wk after birth. Within 14 d,
PRR-knockout mice developed nephrotic syndrome, albuminuria with podocyte foot-process
fusion, and cytoskeletal changes. Podocyte-specific PRR deletion also led to disturbed
processing of multivesicular bodies and enrichment of autophagosomal (LC3) and …