[PDF][PDF] Pathology and bacteriology of early lesions in leprosy

DS Ridley - Int J Lepr Other Mycobact Dis, 1971 - ila.ilsl.br
DS Ridley
Int J Lepr Other Mycobact Dis, 1971ila.ilsl.br
RESULTS AND DISCUSSION Classification. The patients can be pla (~ conveniently in four
groups, according to their degree of success in restricting the in-fection to a single site and in
restraining th< o Jl1l11tiplication of bacilli. The original grouping, howcver, was made on a
purely histologic basis; it"'as found only later that this correlated with evidence of resistance.
In group I the essential feature wa, io\'a· sion of the epidermis by lymphocytes (Fi, 1), or by
epithelioid cell granuloma wbiO: eroded the basal layer and was to somi extent …
RESULTS AND DISCUSSION Classification. The patients can be pla (~ conveniently in four groups, according to their degree of success in restricting the in-fection to a single site and in restraining th< o Jl1l11tiplication of bacilli. The original grouping, howcver, was made on a purely histologic basis; it"'as found only later that this correlated with evidence of resistance. In group I the essential feature wa, io\'a· sion of the epidermis by lymphocytes (Fi, 1), or by epithelioid cell granuloma wbiO: eroded the basal layer and was to somi extent intraepidermal. No acid-fast bacilli (AFB) were found in any of the eight cases in this group_ The lesions wetf. confined to a single site, though there", as f tendency to develop satellite lesions or tubercles. This group was judged, thereFore. to have maximal resistance. In group II there was a small epithe1ioJa cell granuloma originating within a nt'1't bundle, usually in the deep dermis. In most
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