Regulation of type 2 innate lymphoid cell–dependent airway hyperreactivity by butyrate
Background Allergic asthma is characterized by airway hyperreactivity (AHR) and
inflammation driven by aberrant TH 2 responses. Type 2 innate lymphoid cells (ILC2s) are a
critical source of the TH 2 cytokines IL-5 and IL-13, which promote acute asthma
exacerbation. Short-chain fatty acids (SCFAs) have been shown to attenuate T cell–
mediated allergic airway inflammation. However, their role in regulation of ILC2-driven AHR
and lung inflammation remains unknown. Objective We investigated the immunomodulatory …
inflammation driven by aberrant TH 2 responses. Type 2 innate lymphoid cells (ILC2s) are a
critical source of the TH 2 cytokines IL-5 and IL-13, which promote acute asthma
exacerbation. Short-chain fatty acids (SCFAs) have been shown to attenuate T cell–
mediated allergic airway inflammation. However, their role in regulation of ILC2-driven AHR
and lung inflammation remains unknown. Objective We investigated the immunomodulatory …