[HTML][HTML] Prognostic role of high B7-H4 expression in patients with solid tumors: a meta-analysis
X Song, Y Shao, W Gu, C Xu, H Mao, H Pei, J Jiang - Oncotarget, 2016 - ncbi.nlm.nih.gov
X Song, Y Shao, W Gu, C Xu, H Mao, H Pei, J Jiang
Oncotarget, 2016•ncbi.nlm.nih.govBackground Recently, many studies have shown that B7-H4 exhibits altered expression in
various cancers. We performed a meta-analysis to evaluate the prognostic role of B7-H4
expression in solid tumors. Results Data from 18 observational studies and 2467 patients
were summarized. An elevated baseline B7-H4 was significantly associated with worse OS
(pooled HR= 1.79; 95% CI= 1.56–2.06). Differences across subgroups of tumor type,
patients' ethnicity, analysis type, HR obtain method and cut-off value were not significant …
various cancers. We performed a meta-analysis to evaluate the prognostic role of B7-H4
expression in solid tumors. Results Data from 18 observational studies and 2467 patients
were summarized. An elevated baseline B7-H4 was significantly associated with worse OS
(pooled HR= 1.79; 95% CI= 1.56–2.06). Differences across subgroups of tumor type,
patients' ethnicity, analysis type, HR obtain method and cut-off value were not significant …
Abstract
Background
Recently, many studies have shown that B7-H4 exhibits altered expression in various cancers. We performed a meta-analysis to evaluate the prognostic role of B7-H4 expression in solid tumors.
Results
Data from 18 observational studies and 2467 patients were summarized. An elevated baseline B7-H4 was significantly associated with worse OS (pooled HR= 1.79; 95% CI= 1.56–2.06). Differences across subgroups of tumor type, patients' ethnicity, analysis type, HR obtain method and cut-off value were not significant (P D= 0.313, P D= 0.716, P D= 0.896, P D= 0.290 and P D= 0.153, respectively). Furthermore, patients with high B7-H4 had a significantly shorter DFS (pooled HR= 2.12; 95% CI= 1.45–3.09).
Materials and Methods
We searched PubMed, Embase and the Cochrane Library (last update by November 26, 2015) to identify studies assessing the effect of B7-H4 on survival of cancer patients. Pooled hazard ratios (HRs) for overall survival (OS) and disease-free survival (DFS) were estimated using fixed-effects models and random-effects models respectively.
Conclusions
This meta-analysis clarified that high B7-H4 expression in tissue was significantly associated with poor survival in patients with solid tumors. Future clinical studies are warranted to determine whether B7-H4 blockade has a favorable effect on disease recurrence and mortality.
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