PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond
BM Marte, J Downward - Trends in biochemical sciences, 1997 - cell.com
BM Marte, J Downward
Trends in biochemical sciences, 1997•cell.comPKB/Akt is a serine/threonine kinase that contains a pleckstrin-homology (PH) domain and is
activated in response to growth-factor treatment of cells by a mechanism involving
phosphoinositide 3-OH kinase. PKB/Akt provides a survival signal that protects cells from
apoptosis induced by various stresses, perhaps explaining its discovery as a retroviral
oncogene and its amplification in many human tumours.
activated in response to growth-factor treatment of cells by a mechanism involving
phosphoinositide 3-OH kinase. PKB/Akt provides a survival signal that protects cells from
apoptosis induced by various stresses, perhaps explaining its discovery as a retroviral
oncogene and its amplification in many human tumours.
Abstract
PKB/Akt is a serine/threonine kinase that contains a pleckstrin-homology (PH) domain and is activated in response to growth-factor treatment of cells by a mechanism involving phosphoinositide 3-OH kinase. PKB/Akt provides a survival signal that protects cells from apoptosis induced by various stresses, perhaps explaining its discovery as a retroviral oncogene and its amplification in many human tumours.
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