[HTML][HTML] Infections in patients with diabetes mellitus

N Joshi, GM Caputo, MR Weitekamp… - New England Journal …, 1999 - Mass Medical Soc
N Joshi, GM Caputo, MR Weitekamp, AW Karchmer
New England Journal of Medicine, 1999Mass Medical Soc
Contrary to common belief, the association between diabetes mellitus and increased
susceptibility to infection in general is not supported by strong evidence. 1, 2 However, many
specific infections are more common in diabetic patients, and some occur almost exclusively
in them. Other infections occur with increased severity and are associated with an increased
risk of complications in patients with diabetes. Several aspects of immunity are altered in
patients with diabetes. Polymorphonuclear leukocyte function is depressed, particularly …
Contrary to common belief, the association between diabetes mellitus and increased susceptibility to infection in general is not supported by strong evidence.1,2 However, many specific infections are more common in diabetic patients, and some occur almost exclusively in them. Other infections occur with increased severity and are associated with an increased risk of complications in patients with diabetes.
Several aspects of immunity are altered in patients with diabetes. Polymorphonuclear leukocyte function is depressed, particularly when acidosis is also present. Leukocyte adherence, chemotaxis, and phagocytosis may be affected.35 Antioxidant systems involved in bactericidal activity may also be impaired.6 The . . .
The New England Journal Of Medicine