[HTML][HTML] Regulation of CXCR4 signaling

JM Busillo, JL Benovic - Biochimica et Biophysica Acta (BBA) …, 2007 - Elsevier
JM Busillo, JL Benovic
Biochimica et Biophysica Acta (BBA)-Biomembranes, 2007Elsevier
The chemokine receptor CXCR4 belongs to the large superfamily of G protein-coupled
receptors, and is directly involved in a number of biological processes including
organogenesis, hematopoiesis, and immune response. Recent evidence has highlighted
the role of CXCR4 in a variety of diseases including HIV, cancer, and WHIM syndrome.
Importantly, the involvement of CXCR4 in cancer metastasis and WHIM syndrome appears
to be due to dysregulation of the receptor leading to enhanced signaling. Herein we review …
The chemokine receptor CXCR4 belongs to the large superfamily of G protein-coupled receptors, and is directly involved in a number of biological processes including organogenesis, hematopoiesis, and immune response. Recent evidence has highlighted the role of CXCR4 in a variety of diseases including HIV, cancer, and WHIM syndrome. Importantly, the involvement of CXCR4 in cancer metastasis and WHIM syndrome appears to be due to dysregulation of the receptor leading to enhanced signaling. Herein we review what is currently known regarding the regulation of CXCR4 and how dysregulation contributes to disease progression.
Elsevier