[HTML][HTML] Gene expression profiling of CD8+ T cells predicts prognosis in patients with Crohn disease and ulcerative colitis

JC Lee, PA Lyons, EF McKinney… - The Journal of …, 2011 - Am Soc Clin Investig
JC Lee, PA Lyons, EF McKinney, JM Sowerby, EJ Carr, F Bredin, HM Rickman
The Journal of clinical investigation, 2011Am Soc Clin Investig
In the 18th century, Thomas Bayes developed his eponymous theorem that teaches us that
pretest probabilities can be altered by new information, such as when game show host
Monty Hall revealed the goat behind one of the remaining doors in “Let's Make A Deal.”
Bayesian analysis is a key feature of many medical decisions. In this issue of the JCI, Lee
and colleagues apply this concept to inflammatory bowel disease to identify gene
expression–based biomarkers of disease severity. Importantly, these biomarkers allowed …
Abstract
In the 18th century, Thomas Bayes developed his eponymous theorem that teaches us that pretest probabilities can be altered by new information, such as when game show host Monty Hall revealed the goat behind one of the remaining doors in “Let’s Make A Deal.” Bayesian analysis is a key feature of many medical decisions. In this issue of the JCI, Lee and colleagues apply this concept to inflammatory bowel disease to identify gene expression–based biomarkers of disease severity. Importantly, these biomarkers allowed patients to be stratified into two groups: those at high risk for disease recurrence or the need for immunosuppressive treatment escalation and those with a more benign disease course.
The Journal of Clinical Investigation