[HTML][HTML] A great majority of GISTs with PDGFRA mutations represent gastric tumors of low or no malignant potential
J Lasota, A Dansonka-Mieszkowska, LH Sobin… - Laboratory …, 2004 - Elsevier
Gastrointestinal stromal tumors (GISTs) are KIT expressing spindle cell, epithelioid and
rarely pleomorphic mesenchymal tumors. The majority of GISTs show gain-of-function KIT
mutations. However, GISTs without KIT mutations and GISTs with weak or lack of
immunohistochemical KIT expression have also been reported. Recently, gain-of-function
mutations in exon 18 (activation loop) and exon 12 (juxtamembrane domain) of the PDGFRA
were identified in such tumors. The purpose of this study was to test the hypothesis that …
rarely pleomorphic mesenchymal tumors. The majority of GISTs show gain-of-function KIT
mutations. However, GISTs without KIT mutations and GISTs with weak or lack of
immunohistochemical KIT expression have also been reported. Recently, gain-of-function
mutations in exon 18 (activation loop) and exon 12 (juxtamembrane domain) of the PDGFRA
were identified in such tumors. The purpose of this study was to test the hypothesis that …