Human cytomegalovirus infection levels in glioblastoma multiforme are of prognostic value for survival
A Rahbar, A Orrego, I Peredo, M Dzabic… - Journal of Clinical …, 2013 - Elsevier
BACKGROUND: Patients with glioblastoma multiforme (GBM) generally live 12–15 months
after diagnosis, despite maximal surgical resection, adjuvant radiotherapy, and
chemotherapy. HCMV has been detected in 90–100% of GBMs. We recently found that low
grade HCMV infection in GBM tumours was highly associated with survival over 18 months
(case–control study). Here, we sought to determine whether low-grade HCMV infection in
GBMs is associated with prolonged survival in a consecutive patient cohort, analysed …
after diagnosis, despite maximal surgical resection, adjuvant radiotherapy, and
chemotherapy. HCMV has been detected in 90–100% of GBMs. We recently found that low
grade HCMV infection in GBM tumours was highly associated with survival over 18 months
(case–control study). Here, we sought to determine whether low-grade HCMV infection in
GBMs is associated with prolonged survival in a consecutive patient cohort, analysed …