Human CD40 ligand–expressing type 3 innate lymphoid cells induce IL-10–producing immature transitional regulatory B cells
ZI Komlósi, N Kovács, W van de Veen, AI Kirsch… - Journal of Allergy and …, 2018 - Elsevier
Background Type 3 innate lymphoid cells (ILC3s) are involved in maintenance of mucosal
homeostasis; however, their role in immunoregulation has been unknown. Immature
transitional regulatory B (itBreg) cells are innate-like B cells with immunosuppressive
properties, and the in vivo mechanisms by which they are induced have not been fully
clarified. Objective We aimed to investigate the ILC3–B-cell interaction that probably takes
place in human tonsils. Methods ILC3s were isolated from peripheral blood and palatine …
homeostasis; however, their role in immunoregulation has been unknown. Immature
transitional regulatory B (itBreg) cells are innate-like B cells with immunosuppressive
properties, and the in vivo mechanisms by which they are induced have not been fully
clarified. Objective We aimed to investigate the ILC3–B-cell interaction that probably takes
place in human tonsils. Methods ILC3s were isolated from peripheral blood and palatine …