Neutrophils are a major source of the epithelial barrier disrupting cytokine oncostatin M in patients with mucosal airways disease
KL Pothoven, JE Norton, LA Suh, RG Carter… - Journal of Allergy and …, 2017 - Elsevier
Background We have previously shown that oncostatin M (OSM) levels are increased in
nasal polyps (NPs) of patients with chronic rhinosinusitis (CRS), as well as in
bronchoalveolar lavage fluid, after segmental allergen challenge in allergic asthmatic
patients. We also showed in vitro that physiologic levels of OSM impair barrier function in
differentiated airway epithelium. Objective We sought to determine which hematopoietic or
resident cell type or types were the source of the OSM expressed in patients with mucosal …
nasal polyps (NPs) of patients with chronic rhinosinusitis (CRS), as well as in
bronchoalveolar lavage fluid, after segmental allergen challenge in allergic asthmatic
patients. We also showed in vitro that physiologic levels of OSM impair barrier function in
differentiated airway epithelium. Objective We sought to determine which hematopoietic or
resident cell type or types were the source of the OSM expressed in patients with mucosal …