Claudin-18 deficiency is associated with airway epithelial barrier dysfunction and asthma
K Sweerus, M Lachowicz-Scroggins, E Gordon… - Journal of Allergy and …, 2017 - Elsevier
Background Epithelial barrier dysfunction and increased permeability may contribute to
antigen sensitization and disease progression in asthma. Claudin-18.1 is the only known
lung-specific tight junction protein, but its contribution to airway barrier function or asthma is
unclear. Objectives We sought to test the hypotheses that claudin-18 is a determinant of
airway epithelial barrier function that is downregulated by IL-13 and that claudin-18
deficiency results in increased aeroantigen sensitization and airway hyperresponsiveness …
antigen sensitization and disease progression in asthma. Claudin-18.1 is the only known
lung-specific tight junction protein, but its contribution to airway barrier function or asthma is
unclear. Objectives We sought to test the hypotheses that claudin-18 is a determinant of
airway epithelial barrier function that is downregulated by IL-13 and that claudin-18
deficiency results in increased aeroantigen sensitization and airway hyperresponsiveness …