Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples

KJ Baines, JL Simpson, LG Wood, RJ Scott… - Journal of Allergy and …, 2011 - Elsevier
BACKGROUND: Previous studies have identified clinical or inflammatory phenotypes of
asthma on the basis of clinical and demographic parameters or sputum cell counts;
however, few studies have defined transcriptional phenotypes of asthma. OBJECTIVE: To
investigate asthma phenotypes at a transcriptional level by using gene expression profiling
of induced sputum. METHODS: Induced sputum samples were collected from 59 people with
asthma with a mean age of 58 years and an FEV1% predicted of 76%, and 69% were taking …