MicroRNA-9 regulates steroid-resistant airway hyperresponsiveness by reducing protein phosphatase 2A activity
JJ Li, HL Tay, S Maltby, Y Xiang, F Eyers… - Journal of allergy and …, 2015 - Elsevier
Background Steroid-resistant asthma is a major clinical problem that is linked to activation of
innate immune cells. Levels of IFN-γ and LPS are often increased in these patients.
Cooperative signaling between IFN-γ/LPS induces macrophage-dependent steroid-resistant
airway hyperresponsiveness (AHR) in mouse models. MicroRNAs (miRs) are small
noncoding RNAs that regulate the function of innate immune cells by controlling mRNA
stability and translation. Their role in regulating glucocorticoid responsiveness and AHR …
innate immune cells. Levels of IFN-γ and LPS are often increased in these patients.
Cooperative signaling between IFN-γ/LPS induces macrophage-dependent steroid-resistant
airway hyperresponsiveness (AHR) in mouse models. MicroRNAs (miRs) are small
noncoding RNAs that regulate the function of innate immune cells by controlling mRNA
stability and translation. Their role in regulating glucocorticoid responsiveness and AHR …