Chronic rhinosinusitis (CRS), although possibly overdiagnosed, is associated with a high
burden of disease and is often difficult to treat in those truly affected. Recent research has
demonstrated that inflammatory signatures of CRS vary around the world, with less
eosinophilic and more neutrophilic inflammation found in Asia compared with Europe and
North America. Although in the Western world about 80% of nasal polyps carry a type 2
signature, this might be between 20% and 60% in China and Korea or Thailand …