[HTML][HTML] The false alarm hypothesis: Food allergy is associated with high dietary advanced glycation end-products and proglycating dietary sugars that mimic alarmins
PK Smith, M Masilamani, XM Li, HA Sampson - Journal of Allergy and …, 2017 - Elsevier
The incidence of food allergy has increased dramatically in the last few decades in
westernized developed countries. We propose that the Western lifestyle and diet promote
innate danger signals and immune responses through production of “alarmins.” Alarmins
are endogenous molecules secreted from cells undergoing nonprogrammed cell death that
signal tissue and cell damage. High molecular group S (HMGB1) is a major alarmin that
binds to the receptor for advanced glycation end-products (RAGE). Advanced glycation end …
westernized developed countries. We propose that the Western lifestyle and diet promote
innate danger signals and immune responses through production of “alarmins.” Alarmins
are endogenous molecules secreted from cells undergoing nonprogrammed cell death that
signal tissue and cell damage. High molecular group S (HMGB1) is a major alarmin that
binds to the receptor for advanced glycation end-products (RAGE). Advanced glycation end …