TGF-β1–induced phospholamban expression alters esophageal smooth muscle cell contraction in patients with eosinophilic esophagitis
LY Beppu, AA Anilkumar, RO Newbury, R Dohil… - Journal of allergy and …, 2014 - Elsevier
Background Eosinophilic esophagitis (EoE) is a chronic antigen-mediated disease
characterized by esophageal eosinophilia, remodeling, and fibrosis. TGF-β1 is a central
regulator of EoE remodeling and increases esophageal smooth muscle (ESM) cell
contraction. Objective In this study we aimed to understand the molecular mechanisms by
which TGF-β1 could induce ESM cell contraction. Methods We used primary human ESM
cells and esophageal myofibroblasts (EMFs) to assess the mechanisms of TGF-β1–induced …
characterized by esophageal eosinophilia, remodeling, and fibrosis. TGF-β1 is a central
regulator of EoE remodeling and increases esophageal smooth muscle (ESM) cell
contraction. Objective In this study we aimed to understand the molecular mechanisms by
which TGF-β1 could induce ESM cell contraction. Methods We used primary human ESM
cells and esophageal myofibroblasts (EMFs) to assess the mechanisms of TGF-β1–induced …