Twin and family studies reveal strong environmental and weaker genetic cues explaining heritability of eosinophilic esophagitis
ES Alexander, LJ Martin, MH Collins, LC Kottyan… - Journal of Allergy and …, 2014 - Elsevier
Background Eosinophilic esophagitis (EoE) is a chronic antigen-driven allergic inflammatory
disease, likely involving the interplay of genetic and environmental factors, yet their
respective contributions to heritability are unknown. Objective To quantify the risk associated
with genes and environment on familial clustering of EoE. Methods Family history was
obtained from a hospital-based cohort of 914 EoE probands (n= 2192 first-degree “Nuclear-
Family” relatives) and an international registry of monozygotic and dizygotic twins/triplets (n …
disease, likely involving the interplay of genetic and environmental factors, yet their
respective contributions to heritability are unknown. Objective To quantify the risk associated
with genes and environment on familial clustering of EoE. Methods Family history was
obtained from a hospital-based cohort of 914 EoE probands (n= 2192 first-degree “Nuclear-
Family” relatives) and an international registry of monozygotic and dizygotic twins/triplets (n …