Regulation of the IgE isotype switch: new insights on cytokine signals and the functions of ε germline transcripts
HC Oettgen - Current opinion in immunology, 2000 - Elsevier
HC Oettgen
Current opinion in immunology, 2000•ElsevierIn allergic responses, B cells are driven to undergo an immunoglobulin isotype switch,
shifting from IgM to IgE synthesis. This process involves the rearrangment of germline DNA
in the immunoglobulin heavy-chain locus and is stimulated by cytokines (IL-4 and IL-13) and
CD40 activation. It is now evident that cytokine-induced 'germline'ε-RNA transcripts
associate with DNA in the genomic switch region (Sε) to form DNA–RNA hybrid structures,
which target nucleases in for deletional switch recombination. Alterations in cytokine …
shifting from IgM to IgE synthesis. This process involves the rearrangment of germline DNA
in the immunoglobulin heavy-chain locus and is stimulated by cytokines (IL-4 and IL-13) and
CD40 activation. It is now evident that cytokine-induced 'germline'ε-RNA transcripts
associate with DNA in the genomic switch region (Sε) to form DNA–RNA hybrid structures,
which target nucleases in for deletional switch recombination. Alterations in cytokine …
In allergic responses, B cells are driven to undergo an immunoglobulin isotype switch, shifting from IgM to IgE synthesis. This process involves the rearrangment of germline DNA in the immunoglobulin heavy-chain locus and is stimulated by cytokines (IL-4 and IL-13) and CD40 activation. It is now evident that cytokine-induced ‘germline’ ε-RNA transcripts associate with DNA in the genomic switch region (Sε) to form DNA–RNA hybrid structures, which target nucleases in for deletional switch recombination. Alterations in cytokine production and signaling affect the efficiency of this process and are associated with inherited predisposition to allergy.
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