[HTML][HTML] Pediatric severe asthma with fungal sensitization is mediated by steroid-resistant IL-33
S Castanhinha, R Sherburn, S Walker, A Gupta… - Journal of Allergy and …, 2015 - Elsevier
Background The mechanism underlying severe asthma with fungal sensitization (SAFS) is
unknown. IL-33 is important in fungus-induced asthma exacerbations, but its role in fungal
sensitization is unexplored. Objective We sought to determine whether fungal sensitization
in children with severe therapy-resistant asthma is mediated by IL-33. Methods Eighty-two
children (median age, 11.7 years; 63% male) with severe therapy-resistant asthma were
included. SAFS (n= 38) was defined as specific IgE or skin prick test response positivity to …
unknown. IL-33 is important in fungus-induced asthma exacerbations, but its role in fungal
sensitization is unexplored. Objective We sought to determine whether fungal sensitization
in children with severe therapy-resistant asthma is mediated by IL-33. Methods Eighty-two
children (median age, 11.7 years; 63% male) with severe therapy-resistant asthma were
included. SAFS (n= 38) was defined as specific IgE or skin prick test response positivity to …