[HTML][HTML] Alternaria-derived serine protease activity drives IL-33–mediated asthma exacerbations
RJ Snelgrove, LG Gregory, T Peiró, S Akthar… - Journal of allergy and …, 2014 - Elsevier
Background The fungal allergen Alternaria alternata is implicated in severe asthma and
rapid onset life-threatening exacerbations of disease. However, the mechanisms that
underlie this severe pathogenicity remain unclear. Objective We sought to investigate the
mechanism whereby Alternaria was capable of initiating severe, rapid onset allergic
inflammation. Methods IL-33 levels were quantified in wild-type and ST2−/− mice that lacked
the IL-33 receptor given inhaled house dust mite, cat dander, or Alternaria, and the effect of …
rapid onset life-threatening exacerbations of disease. However, the mechanisms that
underlie this severe pathogenicity remain unclear. Objective We sought to investigate the
mechanism whereby Alternaria was capable of initiating severe, rapid onset allergic
inflammation. Methods IL-33 levels were quantified in wild-type and ST2−/− mice that lacked
the IL-33 receptor given inhaled house dust mite, cat dander, or Alternaria, and the effect of …