Background Most asthma begins in the first years of life. This early onset cannot be
attributed merely to genetic factors because the prevalence of asthma is increasing.
Epidemiologic studies have indicated roles for prenatal and early childhood exposures,
including exposure to diesel exhaust. However, little is known about the mechanisms. This is
largely due to a paucity of animal models. Objective We aimed to develop a mouse model of
asthma susceptibility through prenatal exposure to diesel exhaust. Methods Pregnant …