Increased frequency of dual-positive TH2/TH17 cells in bronchoalveolar lavage fluid characterizes a population of patients with severe asthma
C Irvin, I Zafar, J Good, D Rollins, C Christianson… - Journal of allergy and …, 2014 - Elsevier
Background TH 2 cells can further differentiate into dual-positive TH 2/TH 17 cells. The
presence of dual-positive TH 2/TH 17 cells in the airways and their effect on asthma severity
are unknown. Objective We sought to study dual-positive TH 2/TH 17 cells in
bronchoalveolar lavage (BAL) fluid from asthmatic patients, examine their response to
glucocorticoids, and define their relevance for disease severity. Methods Bronchoscopy and
lavage were performed in 52 asthmatic patients and 25 disease control subjects. TH 2 and …
presence of dual-positive TH 2/TH 17 cells in the airways and their effect on asthma severity
are unknown. Objective We sought to study dual-positive TH 2/TH 17 cells in
bronchoalveolar lavage (BAL) fluid from asthmatic patients, examine their response to
glucocorticoids, and define their relevance for disease severity. Methods Bronchoscopy and
lavage were performed in 52 asthmatic patients and 25 disease control subjects. TH 2 and …