Allergic disease prevalence has increased significantly in recent decades. Primary
prevention efforts are being guided by study of the exposome (or collective environmental
exposures beginning during the prenatal period) to identify modifiable factors that affect
allergic disease risk. In this review we explore the evidence supporting a relationship
between key components of the external exposome in the prenatal and early-life periods
and their effect on atopy development focused on microbial, allergen, and air pollution …