Comparison of plaque-and flow cytometry-based methods for measuring dengue virus neutralization
AA Kraus, W Messer, LB Haymore… - Journal of clinical …, 2007 - Am Soc Microbiol
AA Kraus, W Messer, LB Haymore, AM De Silva
Journal of clinical microbiology, 2007•Am Soc MicrobiolAs dengue vaccines enter clinical trials, there is a need for rapid and quantitative assays to
measure neutralization. We have developed flow-based neutralization assays which
generated results similar to those generated by the established, plaque reduction
neutralization test. The flow assays are an improvement, as they use human cells and allow
for high-throughput screening.
measure neutralization. We have developed flow-based neutralization assays which
generated results similar to those generated by the established, plaque reduction
neutralization test. The flow assays are an improvement, as they use human cells and allow
for high-throughput screening.
Abstract
As dengue vaccines enter clinical trials, there is a need for rapid and quantitative assays to measure neutralization. We have developed flow-based neutralization assays which generated results similar to those generated by the established, plaque reduction neutralization test. The flow assays are an improvement, as they use human cells and allow for high-throughput screening.
American Society for Microbiology