Expression of indoleamine 2, 3-dioxygenase in metastatic pancreatic ductal adenocarcinoma recruits regulatory T cells to avoid immune detection
A Witkiewicz, TK Williams, J Cozzitorto… - Journal of the American …, 2008 - Elsevier
BACKGROUND: The mechanism by which pancreatic ductal adenocarcinoma (PDA) cells
escape immune detection and survive in lymph nodes is poorly understood. One possible
mechanism by which PDA cells can escape immune detection is through upregulation of
indoleamine 2, 3-dioxygenase (IDO), an enzyme that can starve T lymphocytes of
tryptophan. STUDY DESIGN: Seventeen cases of PDA were evaluated by
immunohistochemistry for expression of IDO in tumor cells and the number of Forkhead box …
escape immune detection and survive in lymph nodes is poorly understood. One possible
mechanism by which PDA cells can escape immune detection is through upregulation of
indoleamine 2, 3-dioxygenase (IDO), an enzyme that can starve T lymphocytes of
tryptophan. STUDY DESIGN: Seventeen cases of PDA were evaluated by
immunohistochemistry for expression of IDO in tumor cells and the number of Forkhead box …