Association between endothelial dysfunction and acute brain dysfunction during critical illness
CG Hughes, A Morandi, TD Girard, B Riedel… - The Journal of the …, 2013 - pubs.asahq.org
Background: Acute brain dysfunction (delirium and coma) during critical illness is prevalent
and costly, but the pathophysiology remains unclear. The relationship of acute brain
dysfunction with endothelial function, which is impaired in critical illness and may contribute
to alterations in cerebral blood flow and blood–brain barrier permeability, has not been
studied. This study sought to determine whether systemic endothelial dysfunction is
associated with acute brain dysfunction during critical illness. Methods: In this prospective …
and costly, but the pathophysiology remains unclear. The relationship of acute brain
dysfunction with endothelial function, which is impaired in critical illness and may contribute
to alterations in cerebral blood flow and blood–brain barrier permeability, has not been
studied. This study sought to determine whether systemic endothelial dysfunction is
associated with acute brain dysfunction during critical illness. Methods: In this prospective …