The epidermis protects human subjects from exogenous stressors and helps to maintain
internal fluid and electrolyte homeostasis. Filaggrin is a crucial epidermal protein that is
important for the formation of the corneocyte, as well as the generation of its intracellular
metabolites, which contribute to stratum corneum hydration and pH. The levels of filaggrin
and its degradation products are influenced not only by the filaggrin genotype but also by
inflammation and exogenous stressors. Pertinently, filaggrin deficiency is observed in …