[HTML][HTML] Quantitative proteomic analysis of stratum corneum dysfunction in adult chronic atopic dermatitis
J Winget, D Finlay, KJ Mills, T Huggins… - The Journal of …, 2016 - ncbi.nlm.nih.gov
The Journal of investigative dermatology, 2016•ncbi.nlm.nih.gov
Atopic Dermatits/Eczema (AD) is a common condition in childhood and is also suffered by
approximately 2–3% of adults (Eichenfield et al., 2014). Despite intense scientific
investigation into the genetics of AD, disease-linked loci are associated with a minority of
disease cases (Baurecht et al., 2015), leaving the etiology of spontaneous AD in question.
To better understand the biology of AD and to identify protein markers of disease, we
applied quantitative techniques to identify differential Stratum Corneum (SC) proteins from …
approximately 2–3% of adults (Eichenfield et al., 2014). Despite intense scientific
investigation into the genetics of AD, disease-linked loci are associated with a minority of
disease cases (Baurecht et al., 2015), leaving the etiology of spontaneous AD in question.
To better understand the biology of AD and to identify protein markers of disease, we
applied quantitative techniques to identify differential Stratum Corneum (SC) proteins from …
Atopic Dermatits/Eczema (AD) is a common condition in childhood and is also suffered by approximately 2–3% of adults (Eichenfield et al., 2014). Despite intense scientific investigation into the genetics of AD, disease-linked loci are associated with a minority of disease cases (Baurecht et al., 2015), leaving the etiology of spontaneous AD in question.
To better understand the biology of AD and to identify protein markers of disease, we applied quantitative techniques to identify differential Stratum Corneum (SC) proteins from adult AD patients and normal individuals. Using discovery proteomics we identified over 1000 proteins in the SC, with over 200 differentially identified by condition. Selected proteins were quantified with precise targeted methods. Technical details are described in the Supplementary Materials and Methods (online).
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