BACKGROUND: The clarification of cutaneous dendritic cell subset and the role of thymic
stromal lymphopoietin (TSLP) signaling in epicutaneous sensitization with protein antigens,
as in the development of atopic dermatitis, is a crucial issue. OBJECTIVES: Because TSLP is
highly expressed in the vicinity of Langerhans cells (LCs), we sought to clarify our
hypothesis that LCs play an essential role in epicutaneous sensitization with protein
antigens through TSLP signaling. METHODS: By using Langerin-diphtheria toxin receptor …