Staphylococcal exotoxins are strong inducers of IL-22: A potential role in atopic dermatitis
M Niebuhr, H Scharonow, M Gathmann… - Journal of allergy and …, 2010 - Elsevier
BACKGROUND: Patients with atopic dermatitis (AD) and psoriasis are frequently colonized
with Staphylococcus aureus that produces staphylococcal enterotoxin B (SEB) and α-toxin.
In patients with AD, S aureus colonization is positively correlated with the severity of their
eczema. Moreover, IL-22–producing cells have been shown to accumulate in AD skin and to
correlate with disease severity. OBJECTIVE: To assess IL-22 production in response to SEB
and sublytic α-toxin stimulation in patients with AD and psoriasis compared with healthy …
with Staphylococcus aureus that produces staphylococcal enterotoxin B (SEB) and α-toxin.
In patients with AD, S aureus colonization is positively correlated with the severity of their
eczema. Moreover, IL-22–producing cells have been shown to accumulate in AD skin and to
correlate with disease severity. OBJECTIVE: To assess IL-22 production in response to SEB
and sublytic α-toxin stimulation in patients with AD and psoriasis compared with healthy …