Filaggrin-dependent secretion of sphingomyelinase protects against staphylococcal α-toxin–induced keratinocyte death
AM Brauweiler, L Bin, BE Kim, MK Oyoshi… - Journal of allergy and …, 2013 - Elsevier
BACKGROUND: The skin of patients with atopic dermatitis (AD) has defects in keratinocyte
differentiation, particularly in expression of the epidermal barrier protein filaggrin. AD skin
lesions are often exacerbated by Staphylococcus aureus–mediated secretion of the
virulence factor α-toxin. It is unknown whether lack of keratinocyte differentiation
predisposes to enhanced lethality from staphylococcal toxins. OBJECTIVE: We investigated
whether keratinocyte differentiation and filaggrin expression protect against cell death …
differentiation, particularly in expression of the epidermal barrier protein filaggrin. AD skin
lesions are often exacerbated by Staphylococcus aureus–mediated secretion of the
virulence factor α-toxin. It is unknown whether lack of keratinocyte differentiation
predisposes to enhanced lethality from staphylococcal toxins. OBJECTIVE: We investigated
whether keratinocyte differentiation and filaggrin expression protect against cell death …