Construction and characterisation of a heparan sulphate heptasaccharide microarray
Chemical communications, 2017•pubs.rsc.org
A targeted heptasaccharide library was synthesised to prepare a heparan sulphate (HS)
microarray. The array was probed with two glycan-binding proteins, HS 3-O-
sulphotransferase 1 and antithrombin, demonstrating the binding selectivity between HS
and proteins. The HS microarray technique will accelerate the understanding of the structure
and function relationships of HS.
microarray. The array was probed with two glycan-binding proteins, HS 3-O-
sulphotransferase 1 and antithrombin, demonstrating the binding selectivity between HS
and proteins. The HS microarray technique will accelerate the understanding of the structure
and function relationships of HS.
A targeted heptasaccharide library was synthesised to prepare a heparan sulphate (HS) microarray. The array was probed with two glycan-binding proteins, HS 3-O-sulphotransferase 1 and antithrombin, demonstrating the binding selectivity between HS and proteins. The HS microarray technique will accelerate the understanding of the structure and function relationships of HS.
The Royal Society of Chemistry