IL-25 as a novel therapeutic target in nasal polyps of patients with chronic rhinosinusitis
Background Chronic rhinosinusitis (CRS) with nasal polyps (NPs) in Western populations is
associated with TH 2 cytokine polarization. IL-25, an IL-17 family cytokine, was recently
reported to induce TH 2-type immune responses and to contribute to several allergic
diseases, such as atopic dermatitis and asthma. However, the role of IL-25 in Asian patients
with nasal polyposis remains unclear. Objective We sought to determine the role of IL-25 in
Asian patients with nasal polyposis and CRS. Methods We investigated IL-25 expression …
associated with TH 2 cytokine polarization. IL-25, an IL-17 family cytokine, was recently
reported to induce TH 2-type immune responses and to contribute to several allergic
diseases, such as atopic dermatitis and asthma. However, the role of IL-25 in Asian patients
with nasal polyposis remains unclear. Objective We sought to determine the role of IL-25 in
Asian patients with nasal polyposis and CRS. Methods We investigated IL-25 expression …