IL-31: A new key player in dermatology and beyond
IS Bağci, T Ruzicka - Journal of Allergy and Clinical Immunology, 2018 - Elsevier
IL-31 is a novel cytokine expressed in many human tissues and involved mainly in TH 2-
weighted inflammation. IL-31 signals through a receptor complex consisting of IL-31
receptor α and oncostatin M receptor β. The available data show that IL-31 is strongly linked
with chronic pruritic skin disorders, such as atopic eczema, and represents a novel target for
directed drug therapy. Regulation of immune responses and cellular differentiation and
proliferation are recently elucidated effects of IL-31, suggesting a more complex and diverse …
weighted inflammation. IL-31 signals through a receptor complex consisting of IL-31
receptor α and oncostatin M receptor β. The available data show that IL-31 is strongly linked
with chronic pruritic skin disorders, such as atopic eczema, and represents a novel target for
directed drug therapy. Regulation of immune responses and cellular differentiation and
proliferation are recently elucidated effects of IL-31, suggesting a more complex and diverse …