[HTML][HTML] Glucose starvation increases V-ATPase assembly and activity in mammalian cells through AMP kinase and phosphatidylinositide 3-kinase/Akt signaling
CM McGuire, M Forgac - Journal of Biological Chemistry, 2018 - ASBMB
The vacuolar H+-ATPase (V-ATPase) is an ATP-driven proton pump involved in many
cellular processes. An important mechanism by which V-ATPase activity is controlled is the
reversible assembly of its two domains, namely the peripheral V 1 domain and the integral V
0 domain. Although reversible assembly is conserved across all eukaryotic organisms, the
signaling pathways controlling it have not been fully characterized. Here, we identify glucose
starvation as a novel regulator of V-ATPase assembly in mammalian cells. During acute …
cellular processes. An important mechanism by which V-ATPase activity is controlled is the
reversible assembly of its two domains, namely the peripheral V 1 domain and the integral V
0 domain. Although reversible assembly is conserved across all eukaryotic organisms, the
signaling pathways controlling it have not been fully characterized. Here, we identify glucose
starvation as a novel regulator of V-ATPase assembly in mammalian cells. During acute …