[HTML][HTML] The itinerary of a vesicle component, Aut7p/Cvt5p, terminates in the yeast vacuole via the autophagy/Cvt pathways
WP Huang, SV Scott, J Kim, DJ Klionsky - Journal of biological chemistry, 2000 - ASBMB
Aminopeptidase I (API) is delivered to the yeast vacuole by one of two alternative pathways,
cytoplasm to vacuole targeting (Cvt) or autophagy, depending on nutrient conditions.
Genetic, morphological, and biochemical studies indicate that the two pathways share many
of the same molecular components. The Cvt pathway functions during vegetative growth,
while autophagy is induced during starvation. Both pathways involve the formation of
cytosolic vesicles that fuse with the vacuole. In either case, the mechanism of vesicle …
cytoplasm to vacuole targeting (Cvt) or autophagy, depending on nutrient conditions.
Genetic, morphological, and biochemical studies indicate that the two pathways share many
of the same molecular components. The Cvt pathway functions during vegetative growth,
while autophagy is induced during starvation. Both pathways involve the formation of
cytosolic vesicles that fuse with the vacuole. In either case, the mechanism of vesicle …