Pharmacologic Induction of CD8+ T Cell Memory: Better Living Through Chemistry
Science translational medicine, 2009•science.org
The generation of a robust population of memory T cells is critical for effective vaccine and
cell-based therapies to prevent and treat infectious diseases and cancer. A series of recent
papers have established a new, cell-intrinsic approach in which small molecules target key
metabolic and developmental pathways to enhance the formation and maintenance of
highly functional CD8+ memory T cells. These findings raise the exciting new possibility of
using small molecules, many of which are already approved for human use, for the …
cell-based therapies to prevent and treat infectious diseases and cancer. A series of recent
papers have established a new, cell-intrinsic approach in which small molecules target key
metabolic and developmental pathways to enhance the formation and maintenance of
highly functional CD8+ memory T cells. These findings raise the exciting new possibility of
using small molecules, many of which are already approved for human use, for the …
The generation of a robust population of memory T cells is critical for effective vaccine and cell-based therapies to prevent and treat infectious diseases and cancer. A series of recent papers have established a new, cell-intrinsic approach in which small molecules target key metabolic and developmental pathways to enhance the formation and maintenance of highly functional CD8+ memory T cells. These findings raise the exciting new possibility of using small molecules, many of which are already approved for human use, for the pharmacologic induction of immunologic memory.
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