[HTML][HTML] Isolation of bone marrow mesenchymal stem cells by anti-nerve growth factor receptor antibodies
N Quirici, D Soligo, P Bossolasco, F Servida… - Experimental …, 2002 - Elsevier
OBJECTIVE: Mesenchymal stem cells (MSCs) are a population of multipotent cells that can
proliferate and differentiate into multiple mesodermal tissues. We previously reported that
monoclonal antibodies to the low-affinity nerve growth factor receptor (α-LNGFR) stain bone
marrow (BM) mesenchymal cells. We now show that LNGFR antibodies label primitive
MSCs with high specificity and purity in adult BM, and compare these cells to those isolated
by plastic adherence (PA) and CD45− anti-glycophorin A− selection. MATERIALS AND …
proliferate and differentiate into multiple mesodermal tissues. We previously reported that
monoclonal antibodies to the low-affinity nerve growth factor receptor (α-LNGFR) stain bone
marrow (BM) mesenchymal cells. We now show that LNGFR antibodies label primitive
MSCs with high specificity and purity in adult BM, and compare these cells to those isolated
by plastic adherence (PA) and CD45− anti-glycophorin A− selection. MATERIALS AND …