Eosinophilic esophagitis (EoE) genetic susceptibility is mediated by synergistic interactions between EoE-specific and general atopic disease loci
LJ Martin, H He, MH Collins, JP Abonia… - Journal of Allergy and …, 2018 - Elsevier
Background Eosinophilic esophagitis (EoE) is an esophageal inflammatory disease
associated with atopic diseases. Thymic stromal lymphopoietin (TSLP) and calpain 14
(CAPN14) genetic variations contribute to EoE, but how this relates to atopy is unclear.
Objective The purpose of this study was to explore the relationship between EoE, atopy, and
genetic risk. Methods EoE-atopy enrichment was tested by using 700 patients with EoE and
801 community control subjects. Probing 372 single nucleotide polymorphisms (SNPs) in 63 …
associated with atopic diseases. Thymic stromal lymphopoietin (TSLP) and calpain 14
(CAPN14) genetic variations contribute to EoE, but how this relates to atopy is unclear.
Objective The purpose of this study was to explore the relationship between EoE, atopy, and
genetic risk. Methods EoE-atopy enrichment was tested by using 700 patients with EoE and
801 community control subjects. Probing 372 single nucleotide polymorphisms (SNPs) in 63 …