Responsiveness to respiratory syncytial virus in neonates is mediated through thymic stromal lymphopoietin and OX40 ligand
J Han, A Dakhama, Y Jia, M Wang, W Zeng… - Journal of Allergy and …, 2012 - Elsevier
BACKGROUND: Recent studies revealed a critical role for thymic stromal lymphopoietin
(TSLP) released from epithelial cells and OX40 ligand (OX40L) expressed on dendritic cells
(DCs) in TH2 priming and polarization. OBJECTIVES: We sought to determine the
importance of the TSLP-OX40L axis in neonatal respiratory syncytial virus (RSV) infection.
METHODS: Mice were initially infected with RSV as neonates or adults and reinfected 5
weeks later. Anti-OX40L or anti-TSLP were administered during primary or secondary …
(TSLP) released from epithelial cells and OX40 ligand (OX40L) expressed on dendritic cells
(DCs) in TH2 priming and polarization. OBJECTIVES: We sought to determine the
importance of the TSLP-OX40L axis in neonatal respiratory syncytial virus (RSV) infection.
METHODS: Mice were initially infected with RSV as neonates or adults and reinfected 5
weeks later. Anti-OX40L or anti-TSLP were administered during primary or secondary …